A novel Xenopus acetyltransferase with a dynamic expression in early development
SCIE
SCOPUS
- Title
- A novel Xenopus acetyltransferase with a dynamic expression in early development
- Authors
- Choi, SC; Chang, JY; Han, JK
- Date Issued
- 2001-08-03
- Publisher
- ACADEMIC PRESS INC
- Abstract
- We have isolated a novel acetyltransferase from Xenopus laevis, named Xat-1. Xat-1 cDNA encodes a predicted protein of 846 amino acids that contains tetratricopeptide repeat (TPR) domains mediating protein-protein interactions and a bipartite nuclear localization signal (NLS). Its apparent molecular mass of 98.8 kDa was determined by SDS-PAGE analysis of Xat-1 recombinant protein in vitro translated in rabbit reticulocyte lysate. Xat-1 is homologous to N-terminal acetyltransferase 1 (NAT1), a gene that was originally discovered in yeast. Furthermore, it has many orthologs from human, mouse, Drosophila, C. elegans, and even Arabidopsis, thereby suggesting that these constitute a novel acetyltransferase family whose functions have been not examined. Xat-1 transcripts are expressed at relatively constant levels throughout early embryonic stages. They also exhibit dynamic expression pattern in brain, somites, branchial arches, pronephros, and otic vesicles. (C) 2001 Academic Press.
- Keywords
- Xenopus; acetyltransferase; tetratricopeptide repeat (TPR); bipartite nuclear localization signal; NAT; brain; somite; branchial arches; pronephros; INDUCER
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19454
- DOI
- 10.1006/bbrc.2001.5300
- ISSN
- 0006-291X
- Article Type
- Article
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 285, no. 5, page. 1338 - 1343, 2001-08-03
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