Inhibition of TCR-induced CD8 T cell death by IL-12: Regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12
SCIE
SCOPUS
- Title
- Inhibition of TCR-induced CD8 T cell death by IL-12: Regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12
- Authors
- Lee, SW; Park, Y; Yoo, JK; Choi, SY; Sung, YC
- Date Issued
- 2003-03-01
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Abstract
- In this study we demonstrate the anti-apoptotic effect of IL-12 and its underlying mechanism in CD8 T cells. The prolonged stimulation of CD8 T cells with anti-CD3 alone caused apoptosis mediated by Fas and the caspase signaling pathway. However, costimulation with IL-12 significantly prevented anti-CD3-induced apoptosis of CD8 T cells. IL-12 decreased the number of Fas ligand-positive CD8 T cells and inhibited the activation of caspase-8 and caspase-3. In addition, IL-12 up-regulated cellular FLIPs but not Bcl-2 family proteins or cellular inhibitor of apoptosis proteins. These data suggest that IL-12 provides survival signals to CD8 T cells by down-regulating Fas ligand and up-regulating cellular FLIPs, followed by inhibiting caspase activation, which implies a role for IL-12 in peripheral responses of CD8 T cells in vivo.
- Keywords
- TUMOR-NECROSIS-FACTOR; MEDIATED APOPTOSIS; IFN-GAMMA; IN-VIVO; C-FLIP; SURVIVAL; INTERLEUKIN-12; RECEPTOR-1; IMMUNITY; PROTEINS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/18674
- DOI
- 10.4049/jimmunol.170.5.2456
- ISSN
- 0022-1767
- Article Type
- Article
- Citation
- JOURNAL OF IMMUNOLOGY, vol. 170, no. 5, page. 2456 - 2460, 2003-03-01
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.