DNA-Functionalized Nanochannels for SNP Detection
SCIE
SCOPUS
- Title
- DNA-Functionalized Nanochannels for SNP Detection
- Authors
- Yang, SY; Son, S; Jang, S; Kim, H; Jeon, G; Kim, WJ; Kim, JK
- Date Issued
- 2011-03
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We have developed ultrahigh density array of functionalized nanochannels by using a block copolymer having end di-COOH group. This approach provides a facile route for direct functionalization of wall surface of the nanochannels and immobilization site for molecular recognition agents (MRAs) By using overhanging single-stranded DNA as MRAs, the DNA-functionalized nanochannels showed high resolution to detect a single-base mismatch as well as to discriminate single-mismatched sequence at various locations by hybridization preference with MRAs.
- Keywords
- Single nucleotide polymorphisms (SNPs); functional nanochannels; molecular recognition agent; oligonucleotide; block copolymer; SINGLE; SELECTIVITY; POLYMORPHISMS; COPOLYMERS; MEMBRANES; NANOPORES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17613
- DOI
- 10.1021/NL200357Y
- ISSN
- 1530-6984
- Article Type
- Article
- Citation
- NANO LETTERS, vol. 11, no. 3, page. 1032 - 1035, 2011-03
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.