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Cited 45 time in webofscience Cited 50 time in scopus
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Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide SCIE SCOPUS

Title
Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide
Authors
Ayyadurai, NPrabhu, NSDeepankumar, KJang, YJChitrapriya, NSong, ELee, NKim, SKKim, BGSoundrarajan, NLee, SCha, HJBudisa, NYun, H
Date Issued
2011-04
Publisher
AMER CHEMICAL SOC
Abstract
We describe the simple bioconjugation strategy in combination of periodate chemistry and unnatural amino acid incorporation. The residue specific incorporation of 3,4-dihydroxy-L-phenylalanine can alter the properties of protein to conjugate into the polymers. The homogeneously modified protein will yield quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for widespread use to prepare protein conjugates and synthetic biology applications.
Keywords
IN-VIVO; CHEMISTRY; VACCINES; BIOLOGY; CELLS
URI
https://oasis.postech.ac.kr/handle/2014.oak/17447
DOI
10.1021/BC2000066
ISSN
1043-1802
Article Type
Article
Citation
BIOCONJUGATE CHEMISTRY, vol. 22, no. 4, page. 551 - 555, 2011-04
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차형준CHA, HYUNG JOON
Dept. of Chemical Enginrg
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