NONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation
SCIE
SCOPUS
- Title
- NONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation
- Authors
- Kim, J; Lee, Y; Singha, K; Kim, HW; Shin, JH; Jo, S; Han, DK; Kim, WJ
- Date Issued
- 2011-06
- Publisher
- AMER CHEMICAL SOC
- Abstract
- In recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic-BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127.
- Keywords
- SILICA NANOPARTICLES; POLY(VINYL ALCOHOL); PLATELET-ADHESION; BLOCK-COPOLYMERS; RESTENOSIS; DONOR; INDUCTION; POLYMERS; SCAFFOLD; DELIVERY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17359
- DOI
- 10.1021/BC100405C
- ISSN
- 1043-1802
- Article Type
- Article
- Citation
- BIOCONJUGATE CHEMISTRY, vol. 22, no. 6, page. 1031 - 1038, 2011-06
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