Polymers in Small-Interfering RNA Delivery
SCIE
SCOPUS
- Title
- Polymers in Small-Interfering RNA Delivery
- Authors
- Singha, K; Namgung, R; Kim, WJ
- Date Issued
- 2011-06
- Publisher
- MARY ANN LIEBERT INC
- Abstract
- This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.
- Keywords
- EFFICIENT SIRNA DELIVERY; NUCLEIC-ACID DELIVERY; SKELETAL-MUSCLE CELLS; INHIBITS TUMOR-GROWTH; IN-VIVO; GENE DELIVERY; DRUG-DELIVERY; GOLD NANOPARTICLES; CARBON NANOTUBES; RESPONSIVE POLYMERS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17140
- DOI
- 10.1089/NAT.2011.0293
- ISSN
- 2159-3337
- Article Type
- Article
- Citation
- NUCLEIC ACID THERAPEUTICS, vol. 21, no. 3, page. 133 - 147, 2011-06
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- There are no files associated with this item.
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