Theranostic systems assembled in situ on demand by host-guest chemistry
SCIE
SCOPUS
- Title
- Theranostic systems assembled in situ on demand by host-guest chemistry
- Authors
- Hyuntae Jung; Kyeng Min Park; Jeong-A Yang; Eun Ju Oh; Don-Wook Lee; Kitae Park; Ryu, SH; Hahn, SK; Kim, K
- Date Issued
- 2011-10
- Publisher
- Biomaterials
- Abstract
- Theranostic systems have been explored extensively for a diagnostic therapy in the forms of polymer conjugates, implantable devices, and inorganic nanoparticles. In this work, we report theranostic systems in situ assembled by host-guest chemistry responding to a request. As a model theranostic system on demand, cucurbit[6]uril-conjugated hyaluronate (CB[6]-HA) was synthesized and decorated with FITC-spermidine (spmd) and/or formyl peptide receptor like 1 (FPRL1) specific peptide-spmd by simple mixing in aqueous solution. The resulting (FITC-spmd and/or peptide-spmd)@CB[6]-HA was successfully applied to the bioimaging of its target-specific delivery to B16F1 cells with HA receptors and its therapeutic signal transduction with elevated Ca(2+) and phosphor-extracellular signal-regulated kinase (pERK) levels in FPRL1-expressing human breast adenocarcinoma (FPRL1/MCF-7) cells. Finally, we could confirm in vitro and in vivo stability of the highly specific host-guest interaction. The on-demand theranostic platform technology using host-guest chemistry can be exploited for various bioimaging, biosensing, drug delivery, and tissue engineering applications. (C) 2011 Elsevier Ltd. All rights reserved.
- Keywords
- Hyaluronic acid; Cucurbituril; Multi-functionality; Host-guest chemistry; Theranostic system; DRUG-DELIVERY; TARGETED NANOPARTICLES; CUCURBITURIL; DERIVATIVES; POLYMERS; RECEPTOR; THERAPEUTICS; PLATFORM; SURFACE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16967
- DOI
- 10.1016/J.BIOMATERIALS.2011.06.060
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 32, no. 30, page. 7687 - 7694, 2011-10
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