Serum IP-10 Levels correlate with the severity of liver histopathology in patients infected with Genotype-1 HCV
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- Title
- Serum IP-10 Levels correlate with the severity of liver histopathology in patients infected with Genotype-1 HCV
- Authors
- You, CR; Park, SH; Jeong, SW; Woo, HY; Bae, SH; Choi, JY; Sung, YC; Yoon, SK
- Date Issued
- 2011-12
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Abstract
- Background/Aims: Interferon-gamma-inducible protein 10 (IP-10) plays important roles in the pathogenesis of hepatitis C virus (HCV) infection. We investigated the association between serum IP-10 levels and liver pathology in patients with chronic HCV infection. Methods: The serum IP-10 concentration was assessed in 85 patients with chronic HCV infection using a solid phase sandwich enzyme-linked immunosorbent assay, and a liver biopsy specimen was obtained. The pathology was scored using the Knodell histologic activity index (HAI). Results: Of the 85 patients, 58 had genotype 1 HCV infection, 21 had genotype non-1, and 6 were undetermined. The serum IP-10 levels did not differ between patients infected with genotype 1 and genotype non-1 (p=0.472). In patients with genotype 1 infection, the total HAI score and the stage of fibrosis were highly correlated with the serum IP-10 level (r=0.555, r=0.578, p<0.001). Furthermore, the serum IP-10 concentrations of patients with severe fibrosis (stages 3, 4) were higher than those of patients with mild fibrosis (stages 0 to 2; 214.4 vs. 72.3 pg/mL, p=0.002) among patients with genotype 1 infection. However, in patients without genotype 1 infection, the histopathology was not associated with the serum IP-10 level. A multivariate analysis showed that serum IP-10 was an independent predictor of fibrosis (stages 3, 4) in patients with genotype 1 infection (odds ratio, 1.034; 95% confidence interval, 1.006 to 1.064; p=0.018). Conclusions: Serum IP-10 concentration was significantly correlated with the severity of liver histology in genotype 1 HCV infection. (Gut Liver 2011;5:506-512)
- Keywords
- Chronic hepatitis C; Fibrosis; Interferon-gamma-inducible protein 10; CHRONIC HEPATITIS-C; VIRUS-INFECTION; INDUCIBLE PROTEIN-10; CHEMOKINE RECEPTORS; MESSENGER-RNA; IFN-GAMMA; T-CELLS; EXPRESSION; LYMPHOCYTES; ACCUMULATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16509
- DOI
- 10.5009/GNL.2011.5.4.506
- ISSN
- 1976-2283
- Article Type
- Article
- Citation
- GUT AND LIVER, vol. 5, no. 4, page. 506 - 512, 2011-12
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