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In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering SCIE SCOPUS

Title
In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering
Authors
Kyeng Min ParkYang, JAHyuntae JungJunseok YeomJi Sun ParkKeun-Hong ParkAllan S. HoffmanHahn, SKKim, K
Date Issued
2012-04
Publisher
AMER CHEMICAL SOC
Abstract
A facile In situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic add (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applications. The strong and selective host-guest interaction between (KM and DAH made possible the supramolecular assembly of CB[6]/DAH-HA hydrogels In the presence of cells. Then, the 3D environment of CB[6]/DAH-HA hydrogels was modularly modified by the simple treatment with various multifunctional tags-CB[6]. Furthermore, we could confirm in situ formation of CB[6]/DAH-HA hydrogels under the skin of nude mice by sequential subcutaneous injections of CB[6]-HA and DAH-HA solutions. The fluorescence of modularly modified fluorescein isothiocyanate (FITC)-CB[6] In the hydrogels was maintained for up toll days, reflecting the feasibility to deliver the proper cues for cellular proliferation and differentiation In the body. Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications.
Keywords
cucurbituril; hyaluronic acid; hydrogels; supramolecular chemistry; tissue engineering; DRUG-DELIVERY; COMPLEXATION; CYCLODEXTRIN; CUCURBITURIL; MICROENVIRONMENTS; COPOLYMERS; CHEMISTRY; EFFICIENT; POLYMER; SYSTEMS
URI
https://oasis.postech.ac.kr/handle/2014.oak/16281
DOI
10.1021/NN204123P
ISSN
1936-0851
Article Type
Article
Citation
ACS NANO, vol. 6, no. 4, page. 2960 - 2968, 2012-04
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김기문KIM, KIMOON
Dept of Chemistry
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