In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering
SCIE
SCOPUS
- Title
- In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering
- Authors
- Kyeng Min Park; Yang, JA; Hyuntae Jung; Junseok Yeom; Ji Sun Park; Keun-Hong Park; Allan S. Hoffman; Hahn, SK; Kim, K
- Date Issued
- 2012-04
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A facile In situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic add (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applications. The strong and selective host-guest interaction between (KM and DAH made possible the supramolecular assembly of CB[6]/DAH-HA hydrogels In the presence of cells. Then, the 3D environment of CB[6]/DAH-HA hydrogels was modularly modified by the simple treatment with various multifunctional tags-CB[6]. Furthermore, we could confirm in situ formation of CB[6]/DAH-HA hydrogels under the skin of nude mice by sequential subcutaneous injections of CB[6]-HA and DAH-HA solutions. The fluorescence of modularly modified fluorescein isothiocyanate (FITC)-CB[6] In the hydrogels was maintained for up toll days, reflecting the feasibility to deliver the proper cues for cellular proliferation and differentiation In the body. Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications.
- Keywords
- cucurbituril; hyaluronic acid; hydrogels; supramolecular chemistry; tissue engineering; DRUG-DELIVERY; COMPLEXATION; CYCLODEXTRIN; CUCURBITURIL; MICROENVIRONMENTS; COPOLYMERS; CHEMISTRY; EFFICIENT; POLYMER; SYSTEMS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16281
- DOI
- 10.1021/NN204123P
- ISSN
- 1936-0851
- Article Type
- Article
- Citation
- ACS NANO, vol. 6, no. 4, page. 2960 - 2968, 2012-04
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