Facile Surface Modification and Application of Temperature Responsive Poly(N-isopropylacrylamide-co-dopamine methacrylamide)
SCIE
SCOPUS
- Title
- Facile Surface Modification and Application of Temperature Responsive Poly(N-isopropylacrylamide-co-dopamine methacrylamide)
- Authors
- Park, JK; Kim, KS; Yeom, J; Jung, HS; Hahn, SK
- Date Issued
- 2012-10-26
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- The temperature-responsive poly(N-isopropylacrylamide) [PNIPAAm] has been exploited for various biomedical applications. In this work, poly(N-isopropylacrylamide-co-dopamine methacrylamide) [P(NIPAAm-co-DMAAm)] was synthesized for facile surface modification and application to cell sheets. 1H NMR, FT-IR, and GPC confirmed the successful synthesis of P(NIPAAm-co-DMAAm). The lower critical solution temperature was measured to be ca. 29.2 degrees C by UVVis spectroscopy. AFM imaging clearly visualized the transient phase transition of the temperature-responsive polymer bound on silicon substrate by coordination bond formation. Furthermore, the adhesive and temperature responsive P(NIPAAm-co-DMAAm) could be successfully applied to the facile preparation of NIH-3T3 fibroblast cell sheets.
- Keywords
- atomic force microscopy; biopolymers; phase behavior; stimuli-responsive polymers; surfaces; DRUG-DELIVERY; DOPAMINE; HYDROGEL; POLYMERS; COATINGS; ADHESION; ANCHOR; GROWTH
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16277
- DOI
- 10.1002/MACP.201200308
- ISSN
- 1022-1352
- Article Type
- Article
- Citation
- MACROMOLECULAR CHEMISTRY AND PHYSICS, vol. 213, no. 20, page. 2130 - 2135, 2012-10-26
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