4-1BB Cutting Edge: Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase.
SCIE
SCOPUS
- Title
- 4-1BB Cutting Edge: Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase.
- Authors
- Lee, SW; Park, Y; Eun, SY; Madireddi, S; Cheroutre, H; Croft, M
- Date Issued
- 2012-09-15
- Publisher
- The American Association of Immunologists.
- Abstract
- Dendritic cells (DC) in the gut promote immune tolerance by expressing retinal dehydrogenase (RALDH), an enzyme that promotes retinoic acid, which aids differentiation of Foxp3(+) inducible regulatory T cells (iTreg) in the intestinal mucosa. How RALDH expression is regulated is unclear. We found that 4-1BB (CD137), a member of the TNFR family, together with CD103, marked mesenteric lymph node DC with the highest level of RALDH activity, and ligation of 4-1BB maintained RALDH expression in these gut DC. Moreover, 4-1BB signals synergized with those through TLR2 or GM-CSFR to promote RALDH activity in undifferentiated DC. Correspondingly, 4-1BB-deficient mice were impaired in their ability to generate iTreg in the GALT when exposed to oral Ag, and 4-1BB-deficient mesenteric lymph node DC displayed weak RALDH activity and were poor at promoting iTreg development. Thus, our data demonstrate a novel activity of 4-1BB in controlling RALDH expression and the regulatory activity of DC. The Journal of Immunology, 2012, 189: 2697-2701.
- Keywords
- T-CELLS; IMMUNE REGULATION; VITAMIN-A; ACID; DIFFERENTIATION; RESPONSES; MICROBIOTA; INDUCTION; SYSTEM
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15984
- DOI
- 10.4049/jimmunol.1201248
- ISSN
- 0022-1767
- Article Type
- Article
- Citation
- JOURNAL OF IMMUNOLOGY, vol. 189, no. 6, page. 2687 - 2701, 2012-09-15
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.