DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
- DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
- Kim, JM; Shin, HI; Cha, SS; Lee, CS; Hong, BS; Lim, S; Jang, HJ; Kim, J; Yang, YR; Kim, YH; Yun, S; Rijal, G; Lee-Kwon, W; Seo, JK; Gho, YS; Ryu, SH; Hur, EM; Suh, PG
- Date Issued
- NATURE PUBLISHING GROUP
- Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.
- Article Type
- NATURE COMMUNICATIONS, vol. 3, page. 1296 - 1306, 2012-12
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