Current status of gene delivery: spotlight on nanomaterial-polymer hybrids
SCIE
SCOPUS
- Title
- Current status of gene delivery: spotlight on nanomaterial-polymer hybrids
- Authors
- Park, J; Kim, WJ
- Date Issued
- 2012-09
- Publisher
- INFORMA HEALTHCARE
- Abstract
- Gene therapy aims to treat human disorders by introducing genetic materials into specific target cells or tissues. Despite the curability for the origin of diseases by restoring missing functionalities, no technical feasibility of gene therapy has been established due to the lack of safe and efficient gene delivery systems. The emergence of nanotechnology has provided an opportunity to create nanomaterials that are suitable for the biomedical applications. Nanomaterials integrated with cationic polymers offer novel platforms that allow not only easy incorporation of genetic materials through electrostatic interactions but also further modifications to be upgraded to theranostics. In this article, current status of gene delivery utilizing hybrid nanomaterials that are composed of novel nanoplatforms and cationic polymers are highlighted. In particular, different strategies employed for the construction of nanomaterial-polymer hybrids are described.
- Keywords
- Gene delivery; nanomaterials; cationic polymers; surface modification; hybrid materials; MESOPOROUS SILICA NANOPARTICLES; COATED GOLD NANOPARTICLES; IRON-OXIDE NANOPARTICLES; EFFICIENT SIRNA DELIVERY; MOLECULAR-WEIGHT POLYETHYLENIMINE; FUNCTIONALIZED CARBON NANOTUBES; SEMICONDUCTOR QUANTUM DOTS; SMALL-INTERFERING RNA; IN-VIVO; DRUG-DELIVERY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15499
- DOI
- 10.3109/1061186X.2012.704634
- ISSN
- 1061-186X
- Article Type
- Article
- Citation
- JOURNAL OF DRUG TARGETING, vol. 20, no. 8, page. 648 - 666, 2012-09
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