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In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes SCIE SCOPUS

Title
In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes
Authors
Koo, JJeon, MOh, YKang, HWKim, JKim, COh, J
Date Issued
2012-12-07
Publisher
IOP Publishing
Abstract
We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 mu M. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
Keywords
CONTRAST AGENTS; GOLD NANOCAGES; BREAST-CANCER; INDOCYANINE GREEN; ULTRASOUND ARRAY; HIGH-RESOLUTION; MICE; TOMOGRAPHY; SYSTEM; BIODISTRIBUTION
URI
https://oasis.postech.ac.kr/handle/2014.oak/15420
DOI
10.1088/0031-9155/57/23/7853
ISSN
0031-9155
Article Type
Article
Citation
PHYSICS IN MEDICINE AND BIOLOGY, vol. 57, no. 23, page. 7853 - 7862, 2012-12-07
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김철홍KIM, CHULHONG
Dept of Electrical Enginrg
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