Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity
SCIE
SCOPUS
- Title
- Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity
- Authors
- Park, J; Kim, J; Singha, K; Han, DK; Park, H; Kim, WJ
- Date Issued
- 2013-11
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). The polymeric support composed of thermosensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68-BPEI-NONOates releases a sufficient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. The antibacterial ability of the released NO was compared to un-treated control or unmodified F68 polymer by using confocal microscopy; F68-BPEI-NONOates demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation also revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68-BPEI-NONOates against resistant strains such as MRSA provides a very simple but highly efficient strategy to combat drug-resistant bacterial infections. (C) 2013 Elsevier Ltd. All rights reserved.
- Keywords
- N-Diazeniumdiolates; Nitric oxide delivery; Antibacterial activity; Methicillin-resistance; RESISTANT STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; MAGNETIC NANOPARTICLES; ANTIMICROBIAL ACTIVITY; SILVER NANOPARTICLES; MUSCLE-CELLS; DELIVERY; PEROXYNITRITE; BACTERIA; PEPTIDE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15202
- DOI
- 10.1016/J.BIOMATERIALS.2013.07.064
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 34, no. 34, page. 8766 - 8775, 2013-11
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