IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
SCIE
SCOPUS
- Title
- IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
- Authors
- Carrette, F; Surh, CD
- Date Issued
- 2012-06
- Publisher
- Seminars in Immunology
- Abstract
- After their development in the thymus, mature T cells are maintained in the periphery by two sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and the cytokine receptor signals from binding IL-7 and IL-15. These signals cooperate to maximize the utility of finite resources to support a diverse pool of mature T cells. It is becoming increasingly clear that multiple mechanisms exist to regulate expression of IL-7R at the transcriptional and post-translational levels. The interplay between TCR signals and IL-7R signals are also important in regulation of IL-7R expression. This review will focus on regulation of T cell homeostasis by IL-7R signaling, with an emphasis on the cross talk between signals from TCR and IL-7R. (C) 2012 Elsevier Ltd. All rights reserved.
- Keywords
- IL-7; CD127; T cells; Homeostasis; Signaling pathways; ACUTE LYMPHOBLASTIC-LEUKEMIA; PERIPHERAL LYMPHOID ORGANS; ADAPTER PROTEIN SIT; INTERLEUKIN-7 RECEPTOR; IN-VIVO; PHOSPHATIDYLINOSITOL 3-KINASE; CUTTING EDGE; ALPHA-CHAIN; POSITIVE SELECTION; OPPOSING FUNCTIONS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15179
- DOI
- 10.1016/J.SMIM.2012.04.010.
- ISSN
- 1044-5323
- Article Type
- Article
- Citation
- Seminars in Immunology, vol. 24, no. 3, page. 209 - 217, 2012-06
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- There are no files associated with this item.
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