Selectively Expanding Subsets of T Cells in Mice by Injection of Interleukin-2/Antibody Complexes: Implications for Transplantation Tolerance
SCIE
SCOPUS
- Title
- Selectively Expanding Subsets of T Cells in Mice by Injection of Interleukin-2/Antibody Complexes: Implications for Transplantation Tolerance
- Authors
- Boyman, O; Krieg, C; Letourneau, S; Webster, K; Surh, CD; Sprent, J
- Date Issued
- 2012-05
- Publisher
- Elsevier Inc.
- Abstract
- The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.
- Keywords
- ANTIBODY COMPLEXES; EXPANSION; CYTOKINES; IL-2
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15178
- DOI
- 10.1016/J.TRANSPROCEED.2012.01.093.
- ISSN
- 0041-1345
- Article Type
- Article
- Citation
- Transplantation Proceedings, vol. 44, no. 4, page. 1032 - 1034, 2012-05
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- There are no files associated with this item.
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