A Study of the Feasibility of Single Molecule Scattering Analysis with X-Ray Free Electron Lasers
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- Title
- A Study of the Feasibility of Single Molecule Scattering Analysis with X-Ray Free Electron Lasers
- Authors
- Kyungtae Kim; Heesoo Kim; Tai-Hee Kang; Ree, M
- Date Issued
- 2014-01
- Publisher
- SPRINGER
- Abstract
- The feasibility of single molecule elastic scattering analysis with the X-ray free electron laser (XFEL) sources in operation and under construction around the world was investigated for various biological and synthetic materials (pepsin, polyethylene, poly(4,4'-oxydiphenylene pyromellitimide), and ferric oxide). It was found that existing XFEL facilities provide coherent pulse X-ray beams with the required energies (8.3-12.4 keV), but their fluxes are too low for single molecule elastic scattering experiment to determine the three-dimensional structures of such molecules. For single molecule scattering, the XFEL facilities need to improve their beam flux density to 2x10(15) to 7x10(18) photons pulse(-1) mu m(-2), depending on the beam energy. However, the existing XFEL facilities' sources were found to enable the elastic scattering analysis of pepsin and synthetic polymers with sample sizes of 1-160 mu m, as well as of ferric oxide with sample sizes of a parts per thousand yen80 nm. These criteria for the sample size can be extended to other soft (biological, organic, and polymer molecules) and hard (molecules containing heavy metals) materials. In addition, the inelastic scattering, absorption, and radiation damage characteristics of the chosen materials when exposed to the XFEL sources were examined.
- Keywords
- X-ray free electron laser; single molecule scattering; elastic scattering; inelastic scattering; absorption; STRUCTURAL EVOLUTION; EXTREME-ULTRAVIOLET; PROTEIN CRYSTALS; RADIATION-DAMAGE; SMALL-ANGLE; DIFFRACTION; POLYETHYLENE; IMIDIZATION; EMISSION; HEMATITE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15163
- DOI
- 10.1007/S13233-014-2015-Z
- ISSN
- 1598-5032
- Article Type
- Article
- Citation
- Macromolecular Research, vol. 22, no. 1, page. 8 - 18, 2014-01
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