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Candida antarctica lipase A and Pseudomonas stutzeri lipase as a pair of stereocomplementary enzymes for the resolution of 1,2-diarylethanols and 1,2-diarylethanamines SCIE SCOPUS

Title
Candida antarctica lipase A and Pseudomonas stutzeri lipase as a pair of stereocomplementary enzymes for the resolution of 1,2-diarylethanols and 1,2-diarylethanamines
Authors
Sol KimYoon Kyung ChoiJieun HongPark, JKIM, MAHN JOO
Date Issued
2013-03-06
Publisher
Elsevier Ltd.
Abstract
Candida antarctica lipase A (CALA) and Pseudomonas stutzeri lipase (PSL) displayed opposite enantioselectivities in the acylation of 1,2-diphenylethanol and 1,2-diphenylethanamine. CALA was (S)-selective while PSL was (R)-selective. In addition, fourteen different 1,2-diarylethanols were tested as the substrates of CALA. It was found that most of them were accepted by CALA with high enantioselectivity. The DKR of five representative substrates by the combination of CALA and a ruthenium-based racemization catalyst provided good yields (82-91%) and acceptable enantiopurities (87-94% ee). (C) 2012 Elsevier Ltd. All rights reserved.
URI
https://oasis.postech.ac.kr/handle/2014.oak/15119
DOI
10.1016/J.TETLET.2012.11.147
ISSN
0040-4039
Article Type
Article
Citation
TETRAHEDRON LETTERS, vol. 54, no. 10, page. 1185 - 1188, 2013-03-06
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김만주KIM, MAHN JOO
Dept of Chemistry
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