An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells
SCIE
SCOPUS
- Title
- An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells
- Authors
- Kim, JM; Choi, JS; Kim, YH; Jin, SH; Lim, S; Jang, HJ; Kim, KT; RYU, SUNG HO; Suh, PG
- Date Issued
- 2013-03
- Publisher
- JOURNAL OF CELLULAR PHYSIOLOGY
- Abstract
- Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell-based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazolepyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone-related diseases and for the study of bone biology. J. Cell. Physiol. 228: 617626, 2013. (C) 2012 Wiley Periodicals, Inc.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15012
- DOI
- 10.1002/JCP.24171
- ISSN
- 0021-9541
- Article Type
- Article
- Citation
- JOURNAL OF CELLULAR PHYSIOLOGY, vol. 228, no. 3, page. 617 - 626, 2013-03
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.