Prevalence of Low Chlorinated Dibenzo-p-dioxin/Dibenzofurans in Human Serum
SCIE
SCOPUS
- Title
- Prevalence of Low Chlorinated Dibenzo-p-dioxin/Dibenzofurans in Human Serum
- Authors
- Park, H; Kim, J; Chang, YS
- Date Issued
- 2013-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Mono- to tri-chlorinated dibenzo-p-dioxin/dibenzofurans (DD/Fs) have not been studied as extensively as the 17 toxic 2,3,7,8-substituted congeners. In this study for the first time, mono- to octa-chlorinated DD/Fs were analyzed for seventy one human serum samples collected from incinerator workers as well as residents living near and far from the facility. The mean concentrations of Sigma Cl1-8DD/Fs and 17-toxic congeners were 1890 and 398 pg g(-1) lipid (11.9 TEQ pg g(-1) lipid), respectively. 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD, and 1,2,3,6,7,8-HxCDD were predominant congeners that accounted for more than 78% of the TEQ concentrations. The profile for polychlorinated dibenzo-p-dioxins (PCDDs) was dominated by the most chlorinated congener, OCDD (>58%), while decreasing concentrations with increasing degree of chlorination were seen for polychlorinated dibenzofurans (PCDFs); MoCDFs (>83%) and DiCDFs (>6%). Sigma CI1-3DD/Fs accounted for 77% of the serum concentrations of Sigma Cl1-8DD/Fs. These findings confirm that human beings are exposed to a large amount of ECl1-3DD/Fs. Moreover, MoCDFs contributed more than 60% of the ECl1-8DD/Fs and was highly correlated with ECl1-8DD/Fs. Thus, 2-MoCDF could be a predictive indicator for ECl(1-3)DDiFs (r s= 0.96), and the combination of 2-MoCDF and OCDD could explain the 95.9% variation in the serum of ECl1-8DD/Fs. These results suggest that low chlorinated DD/Fs should be studied extensively until these low chlorinated congeners will have been elucidated for their toxicities. (C) 2012 Elsevier Ltd. All rights reserved.
- Keywords
- Human serum; PCDD/Fs; Incinerator; Indicator congener; Korea; MUNICIPAL WASTE INCINERATOR; TOXIC EQUIVALENCY FACTORS; POLYCHLORINATED-BIPHENYLS; PCDD/F FORMATION; ISOMER PATTERNS; DIOXINS; COMBUSTION; KOREA; 2-CHLORODIBENZOFURAN; EMISSIONS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14713
- DOI
- 10.1016/J.CHEMOSPHERE.2012.08.062
- ISSN
- 0045-6535
- Article Type
- Article
- Citation
- CHEMOSPHERE, vol. 90, no. 5, page. 1658 - 1663, 2013-02
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