The nuclear medicine production and delivery problem
SCIE
SCOPUS
- Title
- The nuclear medicine production and delivery problem
- Authors
- Lee, J; Kim, BI; Johnson, AL; Lee, K
- Date Issued
- 2014-07-16
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- Half-life is a unique characteristic of radioactive substances used in a variety of medical treatments. Radioisotope F-18 used for diagnosing and monitoring many types of cancers has a half-life of 110 minutes. As such, it requires careful coordination of production and delivery by manufacturers and medical end-users. To model this critical production and delivery problem, we develop a mixed integer program and propose a variant of a large neighborhood search algorithm with various improvement algorithms. We conduct several computational experiments to demonstrate the effectiveness of the proposed approach. The method when applied in a case study shows that improvement in terms of both time and cost is possible in the production and delivery of F-18. (c) 2013 Elsevier B.V. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14481
- DOI
- 10.1016/J.EJOR.2013.12.024
- ISSN
- 0377-2217
- Article Type
- Article
- Citation
- EUROPEAN JOURNAL OF OPERATIONAL RESEARCH, vol. 236, no. 2, page. 461 - 472, 2014-07-16
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