Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(III)–DOPA complexation
SCIE
SCOPUS
- Title
- Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(III)–DOPA complexation
- Authors
- Kim, BJ; Kim, S; Oh, DX; Masic, A; CHA, HYUNG JOON; Hwang, DS
- Date Issued
- 2015-01
- Publisher
- Royal Society of Chemistry
- Abstract
- Marine mussels utilize multiple bidentate complexes formed by Fe((III)) and DOPA in a mussel adhesive protein (fp-1) to reinforce tough and elastic byssal fibers as a specialized underwater adhesive aid. In this study, mussel- inspired electrospun nanofibers were fabricated using a recombinant mussel adhesive protein (rfp-1), Fe((III))- DOPA complexes, and polycaprolactone. The mechanical properties of the fabricated nanofibers were reinforced by the Fe((III))-DOPA complex found in fp-1, which is a key component of the naturally occurring high-performance mussel fiber coating. Experimental results show that the stoichiometry of Fe((III))-DOPA complexes in the nanofibers could be controlled by buffer pH conditions and the stiffness of the nanofiber mat increased linearly with the concentration of the Fe((III))-DOPA complexes, as monitored by resonance Raman spectroscopy. This suggests the potential of Fe((III))-DOPA complexation as an effective strategy for modulating the mechanical properties of nanofibrous biomedical materials by using pH variations.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14257
- DOI
- 10.1039/C4TB01496K
- ISSN
- 2050-750X
- Article Type
- Article
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, no. 1, page. 112 - 118, 2015-01
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