Open Access System for Information Sharing

Login Library

 

Article
Cited 83 time in webofscience Cited 93 time in scopus
Metadata Downloads

In Vivo Residue-Specific Dopa-Incorporated Engineered Mussel Bioglue with Enhanced Adhesion and Water Resistance SCIE SCOPUS

Title
In Vivo Residue-Specific Dopa-Incorporated Engineered Mussel Bioglue with Enhanced Adhesion and Water Resistance
Authors
Yang, BAyyadurai, NYun, HChoi, YSHwang, BHHuang, JLu, QYZeng, HBCha, HJ
Date Issued
2014-12-01
Publisher
WILEY-VCH
Abstract
Misaminoacylation of 3,4-dihydroxyphenylalanine (Dopa) molecules to tRNATyr by endogenous tyrosyl-tRNA synthetase allowed the quantitative replacement of tyrosine residues with a yield of over 90% by an in vivo residue-specific incorporation strategy, to create, for the first time, engineered mussel adhesive proteins (MAPs) in Escherichia coli with a very high Dopa content, close to that of natural MAPs. The Dopa-incorporated MAPs exhibited a superior surface adhesion and water resistance ability by assistance of Dopa-mediated interactions including the oxidative Dopa crosslinking, and furthermore, showed underwater adhesive properties comparable to those of natural MAPs. These results propose promising use of Dopa-incorporated engineered MAPs as bioglues or adhesive hydrogels for practical underwater applications.
URI
https://oasis.postech.ac.kr/handle/2014.oak/14240
DOI
10.1002/ANIE.201406099
ISSN
1433-7851
Article Type
Article
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, no. 49, page. 13360 - 13364, 2014-12-01
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

차형준CHA, HYUNG JOON
Dept. of Chemical Enginrg
Read more

Views & Downloads

Browse