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Cited 76 time in webofscience Cited 84 time in scopus
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In Vivo Residue-Specific Dopa-Incorporated Engineered Mussel Bioglue with Enhanced Adhesion and Water Resistance SCIE SCOPUS

Title
In Vivo Residue-Specific Dopa-Incorporated Engineered Mussel Bioglue with Enhanced Adhesion and Water Resistance
Authors
Yang, BAyyadurai, NYun, HChoi, YSHwang, BHHuang, JLu, QYZeng, HBCha, HJ
Date Issued
2014-12-01
Publisher
WILEY-VCH
Abstract
Misaminoacylation of 3,4-dihydroxyphenylalanine (Dopa) molecules to tRNATyr by endogenous tyrosyl-tRNA synthetase allowed the quantitative replacement of tyrosine residues with a yield of over 90% by an in vivo residue-specific incorporation strategy, to create, for the first time, engineered mussel adhesive proteins (MAPs) in Escherichia coli with a very high Dopa content, close to that of natural MAPs. The Dopa-incorporated MAPs exhibited a superior surface adhesion and water resistance ability by assistance of Dopa-mediated interactions including the oxidative Dopa crosslinking, and furthermore, showed underwater adhesive properties comparable to those of natural MAPs. These results propose promising use of Dopa-incorporated engineered MAPs as bioglues or adhesive hydrogels for practical underwater applications.
URI
https://oasis.postech.ac.kr/handle/2014.oak/14240
DOI
10.1002/ANIE.201406099
ISSN
1433-7851
Article Type
Article
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, no. 49, page. 13360 - 13364, 2014-12-01
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차형준CHA, HYUNG JOON
Dept. of Chemical Enginrg
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