Continuous Recycling of Homogeneous Pd/Cu Catalysts for Cross-Coupling Reactions
SCIE
SCOPUS
- Title
- Continuous Recycling of Homogeneous Pd/Cu Catalysts for Cross-Coupling Reactions
- Authors
- Sharma, S; Basavaraju, KC; Singh, AK; Kim, DP
- Date Issued
- 2014-08-01
- Publisher
- ORGANIC LETTERS
- Abstract
- Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist "Singulair" with efficient continuous homogeneous catalyst recycling.
- Keywords
- HECK REACTION; PALLADIUM(0) CATALYSTS; MICROFLUIDIC SYSTEM; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; SOLUBLE POLYMERS; FLOW CONDITIONS; DRUG DISCOVERY; SOLVENT SYSTEM; CHEMISTRY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/13724
- DOI
- 10.1021/OL501802W
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- ORGANIC LETTERS, vol. 16, no. 15, page. 3974 - 3977, 2014-08-01
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