Stereoselective Synthesis of Highly Substituted α-Silylamines from Silylmethyl Azides under Ru Catalysis
SCIE
SCOPUS
- Title
- Stereoselective Synthesis of Highly Substituted α-Silylamines from Silylmethyl Azides under Ru Catalysis
- Authors
- Jeong, W; Kim, J; Park, J; RHEE, YOUNG HO
- Date Issued
- 2014-12
- Publisher
- WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Abstract
- A synthetic strategy towards highly substituted -silyl homoallylic amines was discovered. The key event is the unique synthesis of N-unsubstituted -silylimines from azide precursors under mild conditions. Of particular note is the unprecedented access to -silylamines possessing multiple stereocenters and functional groups with high diastereo- and enantioselectivity. The synthetic utility of the method was demonstrated by the use of the silyl moiety as the key element that enables late-stage modification for the iminium ion mediated oxidative cyclization.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/13697
- DOI
- 10.1002/EJOC.201403200
- ISSN
- 1434-193X
- Article Type
- Article
- Citation
- European Journal of Organic Chemistry, vol. 2014, no. 34, page. 7577 - 7581, 2014-12
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