Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
SCIE
SCOPUS
- Title
- Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
- Authors
- Hwang, AB; Ryu, EA; Artan, M; Chang, HW; Kabir, MH; Nam, HJ; Lee, D; Yang, JS; Kim, S; Mair, WB; Lee, C; Lee, SS; Lee, SJ
- Date Issued
- 2014-10-21
- Publisher
- NATL ACAD SCIENCES
- Abstract
- Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and mechanism of ROS-induced longevity are poorly understood. Here, we show that a modest increase in ROS increases the immunity and lifespan of C. elegans through feedback regulation by HIF-1 and AMP-activated protein kinase (AMPK). We found that activation of AMPK as well as HIF-1 mediates the longevity response to ROS. We further showed that AMPK reduces internal levels of ROS, whereas HIF-1 amplifies the levels of internal ROS under conditions that increase ROS. Moreover, mitochondrial ROS increase resistance to various pathogenic bacteria, suggesting a possible association between immunity and long lifespan. Thus, AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS.
- Keywords
- aging; mitochondria; immunity; reactive oxygen species; C. elegans; ACTIVATED PROTEIN-KINASE; INCREASING OXIDATIVE STRESS; LIFE-SPAN; C. ELEGANS; UNCOUPLING PROTEIN-2; ELECTRON-TRANSPORT; HYPOXIA; METABOLISM; RESISTANCE; GENES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/13486
- DOI
- 10.1073/PNAS.1411199111
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 111, no. 42, page. E4458 - E4467, 2014-10-21
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