Exosomes neutralize synaptic-plasticity-disrupting activity of A beta assemblies in vivo
SCIE
SCOPUS
- Title
- Exosomes neutralize synaptic-plasticity-disrupting activity of A beta assemblies in vivo
- Authors
- An, K; lgor klyubin; youngkyu kim; Jung Hoon Jung; Alexandra J Mably; Sean T O'Dowd; Timothy Lynch; Daniel Kanmert; Cynthia A Lemere; Gina M Finan; Park, JW; Tae-Won Kim; Dominic M Walsh; Michael J Rowan; Joung-Hun Kim
- Date Issued
- 2013-11-13
- Publisher
- BioMed Central
- Abstract
- Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer's disease (AD)-associated amyloid beta-protein (A beta). Despite their ubiquitous presence and the inclusion of components which can potentially interact with A beta, the role of exosomes in regulating synaptic dysfunction induced by A beta has not been explored. Results: We here provide in vivo evidence that exosomes derived from N2a cells or human cerebrospinal fluid can abrogate the synaptic-plasticity-disrupting activity of both synthetic and AD brain-derived A beta. Mechanistically, this effect involves sequestration of synaptotoxic A beta assemblies by exosomal surface proteins such as PrPC rather than A beta proteolysis. Conclusions: These data suggest that exosomes can counteract the inhibitory action of A beta, which contributes to perpetual capability for synaptic plasticity.
- Keywords
- lzheimer' s disease; A beta; Exosomes; Synaptic plasticity; PrPC; CELLULAR PRION PROTEIN; ALZHEIMERS-DISEASE BRAIN; AMYLOID-BETA; CEREBROSPINAL-FLUID; SECRETED OLIGOMERS; FIBRIL FORMATION; GANGLIOSIDE GM1; MEMORY; RECEPTOR; RELEASE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/13098
- DOI
- 10.1186/1756-6606-6-47
- ISSN
- 1756-6606
- Article Type
- Article
- Citation
- Molecular Brain, vol. 6, no. 1, page. 47, 2013-11-13
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