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Meteorin regulates mesendoderm development by enhancing nodal expression SCIE SCOPUS

Title
Meteorin regulates mesendoderm development by enhancing nodal expression
Authors
Kim, YYJin-Sook MoonMin-chul KwonJuhee ShinSun-Kyoung ImHyun-A KimHAN, JIN KWANYoung-Yun Kong
Date Issued
2014-02-18
Publisher
PUBLIC LIBRARY SCIENCE
Abstract
During gastrulation, distinct lineage specification into three germ layers, the mesoderm, endoderm and ectoderm, occurs through an elaborate harmony between signaling molecules along the embryonic proximo-distal and anterior-posterior axes, and Nodal signaling plays a key role in the early embryonic development governing embryonic axis formation, mesoderm and endoderm specification, and left-right asymmetry determination. However, the mechanism by which Nodal expression is regulated is largely unknown. Here, we show that Meteorin regulates Nodal expression and is required for mesendoderm development. It is highly expressed in the inner cell mass of blastocysts and further in the epiblast and extra-embryonic ectoderm during gastrulation. Genetic ablation of the Meteorin gene resulted in early embryonic lethality, presumably due to impaired lineage allocation and subsequent cell accumulation. Embryoid body culture using Meteorin-null embryonic stem (ES) cells showed reduced Nodal expression and concomitant impairment of mesendoderm specification. Meteorin-null embryos displayed reduced levels of Nodal transcripts before the gastrulation stage, and impaired expression of Goosecoid, a definitive endoderm marker, during gastrulation, while the proximo-distal and anterior-posterior axes and primitive streak formation were preserved. Our results show that Meteorin is a novel regulator of Nodal transcription and is required to maintain sufficient Nodal levels for endoderm formation, thereby providing new insights in the regulation of mesendoderm allocation.
URI
https://oasis.postech.ac.kr/handle/2014.oak/12706
DOI
10.1371/JOURNAL.PONE.0088811
ISSN
1932-6203
Article Type
Article
Citation
PLoS ONE, vol. 9, no. 2, page. E88811 - E88811, 2014-02-18
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한진관HAN, JIN KWAN
Dept of Life Sciences
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