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Neuritin Attenuates Cognitive Function Impairments in Tg2576 Mouse Model of Alzheimer's Disease SCIE SCOPUS

Title
Neuritin Attenuates Cognitive Function Impairments in Tg2576 Mouse Model of Alzheimer's Disease
Authors
Choi, YLee, KRyu, JKim, HGJeong, AYWoo, RSLee, JHHyun, JWHahn, SKim, JHKim, HS
Date Issued
2014-08-07
Publisher
Public Library of Science
Abstract
Neuritin, also known as CPG15, is a neurotrophic factor that was initially discovered in a screen to identify genes involved in activity-dependent synaptic plasticity. Neuritin plays multiple roles in the process of neural development and synaptic plasticity, although its binding receptor(s) and downstream signaling effectors remain unclear. In this study, we found that the cortical and hippocampal expression of neuritin is reduced in the brains of Alzheimer's disease (AD) patients and demonstrated that viral-mediated expression of neuritin in the dentate gyrus of 13-month-old Tg2576 mice, an AD animal model, attenuated a deficit in learning and memory as assessed by a Morris water maze test. We also found that neuritin restored the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures prepared from Tg2576 mice. It was also shown that viral-mediated expression of neuritin in the dentate gyrus of 7-week-old Sprague-Dawley rats increased neurogenesis in the hippocampus. Taken together, our results demonstrate that neuritin restores the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neurons from Tg2576 neurons, and also attenuates cognitive function deficits in Tg2576 mouse model of AD, suggesting that neuritin possesses a therapeutic potential for AD.
URI
https://oasis.postech.ac.kr/handle/2014.oak/12704
DOI
10.1371/JOURNAL.PONE.0104121
ISSN
1932-6203
Article Type
Article
Citation
PLOS ONE, vol. 9, no. 8, page. 104121, 2014-08-07
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김정훈KIM, JOUNG HUN
Dept of Life Sciences
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