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Internal ribosomal entry site-mediated translation is important for rhythmic PERIOD1 expression SCIE SCOPUS

Title
Internal ribosomal entry site-mediated translation is important for rhythmic PERIOD1 expression
Authors
Lee, KHKim, SHKim, DYKIM, SEUNGHWANKim, KT
Date Issued
2012-05-25
Publisher
PUBLIC LIBRARY SCIENCE
Abstract
The mouse PERIOD1 (mPER1) plays an important role in the maintenance of circadian rhythm. Translation of mPer1 is directed by both a cap-dependent process and cap-independent translation mediated by an internal ribosomal entry site (IRES) in the 5' untranslated region (UTR). Here, we compared mPer1 IRES activity with other cellular IRESs. We also found critical region in mPer1 5'UTR for heterogeneous nuclear ribonucleoprotein Q (HNRNPQ) binding. Deletion of HNRNPQ binding region markedly decreased IRES activity and disrupted rhythmicity. A mathematical model also suggests that rhythmic IRES-dependent translation is a key process in mPER1 oscillation. The IRES-mediated translation of mPer1 will help define the post-transcriptional regulation of the core clock genes.
URI
https://oasis.postech.ac.kr/handle/2014.oak/12672
DOI
10.1371/journal.pone.0037936
ISSN
1932-6203
Article Type
Article
Citation
Plos one, vol. 7, no. 5, 2012-05-25
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김경태KIM, KYONG TAI
Dept of Life Sciences
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