Rapid flow synthesis of fenofibrate via scalable flash chemistry with in-line Li recovery
SCIE
SCOPUS
- Title
- Rapid flow synthesis of fenofibrate via scalable flash chemistry with in-line Li recovery
- Authors
- Kawale, Sanket A.; Kang, Dong-Chang; Ahn, Gwang-Noh; Mottafegh, Amirreza; Kang, Ji-Ho; Na, Gi-Su; Kim, Dong-Pyo
- Date Issued
- 2023-12
- Publisher
- Elsevier B.V.
- Abstract
- Flash chemistry controlled organolithium reactions allow redesigning the new economically affordable synthetic routes for life-saving drugs. However, microreactors limit their applications to extend industrial-level productivity. On the other hand, there has been little attention on recycling valuable elements from organic synthesis. In this work, a new compact monolithic metal microreactor was designed to successfully control the lifetime of short-lived organolithium intermediates at a large scale for sub-second scalable synthesis of fenofibrate as an FDA-approved drug for hypertriglyceridemia. Initially, the ultrafast chemistry of highly unstable ArLi intermediate was successfully explored for the synthesis of fenofibrate by its flow-controlled coupling reaction with 4-chlorobenzoyl chloride. As needed, by 3D metal printing of the CAD-CFD simulated works, eight laminated serpentine channels integrated with four flow distributors were constructed in a monolithic metal microreactor, leading to improved productivity up to 1.18 g min−1. At the in-line work-up step, the largely consumed Li was completely recovered for the potential recycling of valuable Li resources in a continuous-flow manner.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/123662
- DOI
- 10.1016/j.cej.2023.147033
- ISSN
- 1385-8947
- Article Type
- Article
- Citation
- Chemical Engineering Journal, vol. 477, 2023-12
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- There are no files associated with this item.
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