A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron
SCIE
SCOPUS
- Title
- A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron
- Authors
- Sharma, Garima; Sharma, Amit; Kim, Inhae; Cha, Dong Gon; Kim, Somi; Park, Eun Seo; Noh, Jae Gyun; Lee, Juhee; Ku, Ja Hyeon; Choi, Yoon Ha; Kong, JungHo; Lee, Haena; Ko, Haeun; Lee, Juhun; Notaro, Anna; Hong, Seol Hee; Rhee, Joon Haeng; Kim, Sang Geon; De Castro, Cristina; Molinaro, Antonio; Shin, Kunyoo; Kim, Sanguk; Kim, Jong Kyoung; Rudra, Dipayan; Im, Sin-Hyeog
- Date Issued
- 2024-05
- Publisher
- Nature Publishing Group
- Abstract
- Here the authors show that a heteropolysaccharide from a commensal bacteria commonly found in the Korean food kimchi is able to bolster antitumor immune responses by instructing tumor-associated macrophages to release lipocalin-2, which sequesters iron away from tumor cells contributing to the immune response to attack these cells. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024..
Innate immune cells generate a multifaceted antitumor immune response, including the conservation of essential nutrients such as iron. These cells can be modulated by commensal bacteria; however, identifying and understanding how this occurs is a challenge. Here we show that the food commensal Lactiplantibacillus plantarum IMB19 augments antitumor immunity in syngeneic and xenograft mouse tumor models. Its capsular heteropolysaccharide is the major effector molecule, functioning as a ligand for TLR2. In a two-pronged manner, it skews tumor-associated macrophages to a classically active phenotype, leading to generation of a sustained CD8+ T cell response, and triggers macrophage ‘nutritional immunity’ to deploy the high-affinity iron transporter lipocalin-2 for capturing and sequestering iron in the tumor microenvironment. This process induces a cycle of tumor cell death, epitope expansion and subsequent tumor clearance. Together these data indicate that food commensals might be identified and developed into ‘oncobiotics’ for a multi-layered approach to cancer therapy. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/123517
- DOI
- 10.1038/s41590-024-01816-x
- ISSN
- 1529-2908
- Article Type
- Article
- Citation
- Nature Immunology, vol. 25, no. 5, page. 790 - 801, 2024-05
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- There are no files associated with this item.
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