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Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

Title
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Authors
Pati, FJANG, JINAHHa, DHKim, SWRhie, JWShim, JHKim, DHCho, DW
POSTECH Authors
JANG, JINAHCho, DW
Date Issued
Jun-2014
Publisher
NATURE PUBLISHING GROUP
Abstract
The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term function. We achieve high cell viability and functionality of the printed dECM structures using our bioprinting method.
The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term function. We achieve high cell viability and functionality of the printed dECM structures using our bioprinting method.
URI
http://oasis.postech.ac.kr/handle/2014.oak/11791
DOI
10.1038/NCOMMS4935
ISSN
2041-1723
Article Type
Article
Citation
NATURE COMMUNICATIONS, vol. 5, 2014-06
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장진아JANG, JIN AH
Dept. of Creative IT Engin.
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