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Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy SCIE SCOPUS

Title
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy
Authors
An, Seong BeomYang, Bo-GieJang, GyeonghuiKim, Do-YeonKim, JiyoungOh, Sung-ManOh, NahyunLee, SangheeMoon, Ji-YeongKim, Jeong-AhKim, Ji-HyunSong, Yoo-JeongHyun, Hye-WonKim, JisooLee, KyungwhaLee, DajeongKwak, Min-JungKim, Byung KwonPark, Young-KyuHong, Chun-PyoKim, Jung HwanLim, Hye SeongRyu, Min SookJin, Hyun-TakLEE, SEUNG WOOChang, Yoon-SeokPark, Hae-SimSung, Young ChulJang, Myoung Ho
Date Issued
2022-12
Publisher
Nature Publishing Group
Abstract
AbstractIgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody approved for therapeutic use, has limited benefits for patients with high IgE levels. Here, we assess a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgETRAP, to reduce the risk of IgG1 Fc-mediated side effects. IgETRAP shows enhanced IgE binding affinity compared to omalizumab. We also see an enhanced therapeutic effect of IgETRAP in food allergy models when combined with Bifidobacterium longum, which results in mast cell number and free IgE levels. The combination of IgETRAP and B. longum may therefore represent a potent treatment for allergic patients with high IgE levels.
URI
https://oasis.postech.ac.kr/handle/2014.oak/113930
DOI
10.1038/s41467-022-33176-1
ISSN
2041-1723
Article Type
Article
Citation
Nature Communications, vol. 13, no. 1, 2022-12
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성영철SUNG, YOUNG CHUL
Dept of Life Sciences
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