Diborylmethyl Group as a Transformable Building Block for the Diversification of Nitrogen-Containing Molecules
SCIE
SCOPUS
- Title
- Diborylmethyl Group as a Transformable Building Block for the Diversification of Nitrogen-Containing Molecules
- Authors
- Hwang, Chiwon; Lee, Yeosan; Kim, Minjae; Seo, Younggyu; Cho, Seung Hwan
- Date Issued
- 2022-09
- Publisher
- John Wiley and Sons Inc
- Abstract
- © 2022 Wiley-VCH GmbH.The development of new approaches to installing diverse carbon fragments to a nitrogen atom has attracted considerable attention in chemical science. While numerous strategies have been devised to forge C(sp3)−N bonds, one conceptually powerful and straightforward approach is to insert a transformable sp3-carbon unit onto a nitrogen atom for modular diversification. Here we describe the successful synthesis of halo-diborylmethanes and their applications to the preparation of nitrogen-substituted diborylmethanes through their homologative coupling with a variety of nitrogen nucleophiles including biologically relevant molecules. This process exhibits a remarkably broad substrate scope, and the usefulness of the obtained compounds is demonstrated by the modular diversification of the diborylmethyl group to access various nitrogen-containing molecules.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/113609
- DOI
- 10.1002/anie.202209079
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- Angewandte Chemie - International Edition, vol. 61, no. 37, 2022-09
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