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Skin Penetration Enhancer-Incorporated Lipid Nanovesicles (SPE-LNV) for Skin Brightening and Wrinkle Treatment SCIE SCOPUS

Title
Skin Penetration Enhancer-Incorporated Lipid Nanovesicles (SPE-LNV) for Skin Brightening and Wrinkle Treatment
Authors
Lee, JihyunNoh, MinjooJang, JihuiLee, Jun BaeHWANG, YOONHOLee, Hyomin
Date Issued
2022-08
Publisher
American Chemical Society
Abstract
In this work, we utilize skin penetration enhancers (SPEs) such as ceramide and fatty acids in lipid nanovesicles to promote the transdermal delivery of active ingredients. These SPE-incorporated lipid nanovesicles (SPE-LNV) interact with the constituents of skin's outermost stratum corneum (SC) layer, enabling even niacinamide and adenosine with high water solubility to effectively permeate through, leading to enhanced skin efficacy. We demonstrate by both in vitro and in vivo skin permeation studies that the SPE-LNV formulation containing both ceramide and fatty acids (LNV-CF) exhibits deeper penetration depth and faster permeation rate compared to conventional lipid nanovesicles (LNV) without SPE as well as LNV-C with only ceramide. Moreover, in vivo clinical trials were also performed to confirm that LNV-CF most effectively mediates the delivery of niacinamide and adenosine, resulting in a substantial decrease in melanin index as well as skin wrinkle compared to the control groups. We envision that the strategy of incorporating both ceramide and fatty acids in lipid nanovesicles offers a simple and convenient route for the rapid and effective delivery of water-soluble active ingredients across the skin barrier layer.
URI
https://oasis.postech.ac.kr/handle/2014.oak/113525
DOI
10.1021/acsami.2c07135
ISSN
1944-8244
Article Type
Article
Citation
ACS Applied Materials and Interfaces, vol. 14, no. 32, page. 36331 - 36340, 2022-08
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이효민Lee, Hyomin
Dept. of Chemical Enginrg
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