Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors
SCIE
SCOPUS
- Title
- Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors
- Authors
- Kang, Ji-Ho; Ahn, Gwang-Noh; Lee, Heekwon; Yim, Se-Jun; Lahore, Santosh; Lee, Hyune-Jea; Kim, Heejin; Kim, Ji Tae; Kim, Dong-Pyo
- Date Issued
- 2022-01
- Publisher
- American Chemical Society
- Abstract
- © Continuous-flow microreactors enable ultrafast chemistry; however, their small capacity restricts industrial-level productivity of pharmaceutical compounds. In this work, scale-up subsecond synthesis of drug scaffolds was achieved via a 16 numbered-up printed metal microreactor (16N-PMR) assembly to render high productivity up to 20 g for 10 min operation. Initially, ultrafast synthetic chemistry of unstable lithiated intermediates in the halogen-lithium exchange reactions of three aryl halides and subsequent reactions with diverse electrophiles were carried out using a single microreactor (SMR). Larger production of the ultrafast synthesis was achieved by devising a monolithic module of 4 numbered-up 3D-printed metal microreactor (4N-PMR) that was integrated by laminating four SMRs and four bifurcation flow distributors in a compact manner. Eventually, the 16N-PMR system for the scalable subsecond synthesis of three drug scaffolds was assembled by stacking four monolithic modules of 4N-PMRs.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/113126
- DOI
- 10.1021/acscentsci.1c00972
- ISSN
- 2374-7943
- Article Type
- Article
- Citation
- ACS Central Science, vol. 8, no. 1, page. 43 - 50, 2022-01
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.