Surfactant‐Stripped Semiconducting Polymer Micelles for Tumor Theranostics and Deep Tissue Imaging in the NIR‐II Window
SCIE
SCOPUS
- Title
- Surfactant‐Stripped Semiconducting Polymer Micelles for Tumor Theranostics and Deep Tissue Imaging in the NIR‐II Window
- Authors
- Ding, Yuanmeng; Park, Byullee; Ye, Jiamin; Wang, Xiaojie; Liu, Gengqi; Yang, Xingyue; Jiang, Zhen; Han, Moongyu; Fan, Yong; Song, Jibin; Kim, Chulhong; Zhang, Yumiao
- Date Issued
- 2022-02
- Publisher
- Wiley - V C H Verlag GmbbH & Co.
- Abstract
- Photoacoustic imaging (PA) in the second near infrared (NIR-II) window presents key advantages for deep tissue imaging owing to reduced light scattering and low background signal from biological structures. Here, a thiadiazoloquinoxaline-based semiconducting polymer (SP) with strong absorption in the NIR-II region is reported. After encapsulation of SP in Pluronic F127 (F127) followed by removal of excess surfactant, a dual functional polymer system named surfactant-stripped semiconductor polymeric micelles (SSS-micelles) are generated with water solubility, storage stability, and high photothermal conversion efficiency, permitting tumor theranostics in a mouse model. SSS-micelles have a wideband absorption in the NIR-II window, allowing for the PA imaging at both 1064 and 1300 nm wavelengths. The PA signal of the SSS-micelles can be detected through 6.5 cm of chicken breast tissue in vitro. In mice or rats, SSS-micelles can be visualized in bladder and intestine overlaid 5 cm (signal to noise ratio, SNR approximate to 17 dB) and 5.8 cm (SNR over 10 dB) chicken breast tissue, respectively. This work demonstrates the SSS-micelles as a nanoplatform for deep tissue theranostics.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109568
- DOI
- 10.1002/smll.202104132
- ISSN
- 1613-6810
- Article Type
- Article
- Citation
- Small, vol. 18, no. 6, 2022-02
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- There are no files associated with this item.
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