A case of hypersensitivity syndrome to both vancomycin and teicoplanin
SCIE
SCOPUS
KCI
- Title
- A case of hypersensitivity syndrome to both vancomycin and teicoplanin
- Authors
- Kwon, HS; Chang, YS; Jeong, YY; Lee, SM; Song-, WJ; Kim, HB; Kim, YK; Cho, SH; Kim, YY; Min, KU
- Date Issued
- 2006-12
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Abstract
- Drug hypersensitivity syndrome to both vancomycin and teicoplanin has not been previously reported. We describe here a 50-yr-old male patient with vertebral osteomyelitis and epidural abscess who developed hypersensitivity syndrome to both vancomycin and teicoplanin. Skin rash, fever, eosinophilia, interstitial pneumonitis, and interstitial nephritis developed following the administration of each drug, an resolved after withdrawing the drugs and treating with high dose corticosteroids. The vertebral osteomyelitis was successfully treated with 6-week course of linezolid without further complications. Skin patch tests for vancomycin and teicoplanin was done 2 months after the recovery; a weak positive result for vancomycin (10% aq., +at D2 and +at D4 with erythema and vesicles; ICDRG scale), and a doubtful result for teicoplanin (4% aq.-at D2 and +/- at D4 with macular erythema; ICDRG scale). We present this case to alert clinicians to the hypersensitivity syndrome that can result from vancomycin and teicoplanin, with possible cross-reactivity, which could potentially be life-threatening.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/10891
- DOI
- 10.3346/jkms.2006.21.6.1108
- ISSN
- 1011-8934
- Article Type
- Article
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 21, no. 6, page. 1108 - 1110, 2006-12
- Files in This Item:
-
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.