Continuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules
SCOPUS
- Title
- Continuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules
- Authors
- Vidyacharan, S.; Ramanjaneyulu, B.T.; Jang, S.; Kim, D.-P.
- Date Issued
- 2019-06
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A continuous-flow homogeneous photocatalytic method has been devised for the direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3-arylated scaffolds of biological interest in a fast (1 min), single-step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technology is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal-free conditions, whereas the reported methods required multiple steps and much longer reaction times (18-24 h).
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107947
- DOI
- 10.1002/cssc.201900736
- ISSN
- 1864-5631
- Article Type
- Article
- Citation
- CHEMSUSCHEM, vol. 12, no. 12, page. 2581 - 2586, 2019-06
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- There are no files associated with this item.
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