Photocatalysis in a multi-capillary assembly microreactor: toward up-scaling the synthesis of 2H-indazoles as drug scaffolds
SCIE
SCOPUS
- Title
- Photocatalysis in a multi-capillary assembly microreactor: toward up-scaling the synthesis of 2H-indazoles as drug scaffolds
- Authors
- Jang, S.; Vidyacharan, S.; Ramanjaneyulu, B.T.; Gyak, K.-W.; Kim, D.-P.
- Date Issued
- 2019-06
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- Visible-light-promoted direct arylation of 2H-indazoles using phenyldiazonium salt enabled a single-step and fast synthesis (<1 min) of C3 arylated products in high yields (>65%) in a capillary microreactor, compared to the slow synthesis (18 h) in a flask. Moreover, scalable photocatalysis of a 2H-indazole based liver X-receptor modulator was performed by devising a compact multi-capillary assembly microreactor composed of vertically aligned 10 capillary tubes connected to 3D printed fluidic fixtures. Eventually, the assembly produced the drug on an similar to 4 gram scale per hour by a one-flow automated process taken for 2.2 min from synthesis to product separation, which would be a breakthrough approach for pharmaceutical production.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107946
- DOI
- 10.1039/c9re00239a
- ISSN
- 2058-9883
- Article Type
- Article
- Citation
- REACTION CHEMISTRY & ENGINEERING, vol. 4, no. 8, page. 1466 - 1471, 2019-06
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- There are no files associated with this item.
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