Quantitative Label-free Terahertz Sensing of Transdermal Nicotine Delivered to Human Skin
SCIE
SCOPUS
KCI
- Title
- Quantitative Label-free Terahertz Sensing of Transdermal Nicotine Delivered to Human Skin
- Authors
- 이경석; 남궁호; 도영웅; 강현아; 김진우; 한해욱
- Date Issued
- 2020-08
- Publisher
- OPTICAL SOC KOREA
- Abstract
- We report the terahertz time-domain spectroscopy (THz-TDS) of transdermal drug delivery in human skin. The time evolution of transdermal nicotine delivery in nicotine patches was assessed by detecting the transmission coefficient of sub-picosecond THz pulses and using a semi-analytic model based on the single-layer effective medium approximation. Using commercial nicotine patches (Nicoderm CQ (R), 7 mg/24 h), THz transmission coefficients were measured to quantitatively analyze the cumulative amounts of nicotine released from the patches in the absence of their detailed specifications, including multilayer structures and optical properties at THz frequencies. The results agreed well with measurements by conventional in vitro and in vivo methods, using a diffusion cell with high-performance liquid chromatography and blood sampling respectively. Our study revealed the ability of the THz-TDS method to be an effective alternative to existing methods for noninvasive and label-free assessments of transdermal drug delivery, showing its high promise for biomedical, pharmaceutical, and cosmetic applications.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107854
- DOI
- 10.3807/COPP.2020.4.4.368
- ISSN
- 2508-7266
- Article Type
- Article
- Citation
- CURRENT OPTICS AND PHOTONICS, vol. 4, no. 4, page. 368 - 372, 2020-08
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.