Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging
SCIE
SCOPUS
- Title
- Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging
- Authors
- Park, J.C.; Kim, D.H.; Song, Y.H.; Cha, H.J.; Seo, J.H.
- Date Issued
- 2020-09
- Publisher
- NLM (Medline)
- Abstract
- The work presented in this report demonstrates that amphiphilic polysaccharide-clasped self-assembly (Amp-SA) with nanometer size, encapsulating hydrophobic nanoparticles (NPs) can be generated via electrohydrodynamic spraying. It is observed that the formation of hydrophobic NP-encapsulated Amp-SA is dependent on the surface chemistry of NPs. The citrate-coated magnetic NPs (MNPs-Cit) were also prepared and compared. The hydrophobic magnetic NP-encapsulated Amp-SA (Amp-SA-M) exhibited around 2.7-2.8-fold higher values in r2 relaxivity than that of MNPs-Cit. In addition, the resulting Amp-SA-M achieved ��17.2-fold higher values in r2/r1 ratios than MNPs-Cit. The enhanced performances in magnetic transverse (r2) relaxivity and r2/r1 ratio as well as the in vivo behavior of Amp-SA-M suggest the potential of Amp-SA-M as a promising MRI nanoprobe. This approach based on the nature-originated amphiphilic biopolymers may provide a novel insight into electrohydrodynamic techniques that have the ability to create various nanostructures, encapsulating high-quality hydrophobic nanomaterials for applications in diverse biotechnology.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107834
- DOI
- 10.1021/acsami.0c07473
- ISSN
- 1944-8244
- Article Type
- Article
- Citation
- ACS applied materials & interfaces, vol. 12, no. 35, page. 38899 - 38905, 2020-09
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- There are no files associated with this item.
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