Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
SCIE
SCOPUS
- Title
- Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
- Authors
- LIM, SOOBIN; CHO, HYUNGDO; 정종헌; JANG, MIN JAE; KIM, HYUNSEOK; CHO, SEUNG HWAN; Lee, Eunsung
- Date Issued
- 2020-09-18
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Transition-metal-catalyzed transformations of the carbon-fluorine bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein we report a practical cobalt-catalyzed silylation of aryl fluorides that uses a cheap electrophilic silicon source with magnesium. This method is compatible with various silicon sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic silicon source.
- Keywords
- CROSS-COUPLING REACTIONS; F BOND ACTIVATION; C-F; OXIDATIVE ADDITION; BORYLATION; COMPLEXES; HALIDES; FUNCTIONALIZATION; POLYFLUOROARENES; MOLECULES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107827
- DOI
- 10.1021/acs.orglett.0c02752
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- ORGANIC LETTERS, vol. 22, no. 18, page. 7387 - 7392, 2020-09-18
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