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A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity SCIE SCOPUS
- Title
- A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity
- Authors
- Vila I.K.; Park M.K.; Setijono S.R.; Yao Y.; Kim H.; Badin P.-M.; Choi S.; Narkar V.; Choi S.-W.; Chung J.; Moro C.; Song S.J.; Song M.S.
- Date Issued
- 2019-07
- Publisher
- The American Society for Clinical Investigation
- Abstract
- Ubiquitin-conjugating enzyme E2O (UBE2O) is expressed preferentially in metabolic tissues, but its role in regulating energy homeostasis has yet to be defined. Here we find that UBE2O is markedly upregulated in obese subjects with type 2 diabetes and show that whole-body disruption of Ube2o in mouse models in vivo results in improved metabolic profiles and resistance to high-fat diet–induced (HFD-induced) obesity and metabolic syndrome. With no difference in nutrient intake, Ube2o
- ISSN
- 2324-7703
- Article Type
- Article
- Citation
- JCI insight, vol. 4, no. 13, 2019-07
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