Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue
- Title
- Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue
- Authors
- Hao, Lam Tan; Park, Sohee; Choy, Seunghwan; Kim, Young-Min; Lee, Seung-Woo; Ok, Yong Sik; Koo, Jun Mo; Hwang, Sung Yeon; Hwang, Dong Soo; Park, Jeyoung; Oh, Dongyeop X.
- Date Issued
- 2021-09
- Publisher
- American Chemical Society
- Abstract
- Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107244
- DOI
- 10.1021/jacsau.1c00193
- ISSN
- 2691-3704
- Article Type
- Article
- Citation
- JACS Au, vol. 1, no. 9, page. 1399 - 1411, 2021-09
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- There are no files associated with this item.
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