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Methylene Blue Microbubbles (MB2) as a Model Dual-Modality Contrast Agent for Ultrasound and Activatable Photoacoustic Imaging SCIE SCOPUS

Title
Methylene Blue Microbubbles (MB2) as a Model Dual-Modality Contrast Agent for Ultrasound and Activatable Photoacoustic Imaging
Authors
Jeon, MSong, WTHuynh, EKim, JKim, JHelfield, BLLeung, BYCGoertz, DEZheng, GOh, JLovell, JFKim, C
Date Issued
2014-01
Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Abstract
Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
URI
https://oasis.postech.ac.kr/handle/2014.oak/10681
DOI
10.1117/1.JBO.19.1.016005
ISSN
1083-3668
Article Type
Article
Citation
Journal of Biomedical Optics, vol. 19, no. 1, page. 16005-1 - 16005-8, 2014-01
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김철홍KIM, CHULHONG
Dept of Electrical Enginrg
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