Niche-specific MHC II and PD-L1 regulate CD4(+)CD8 alpha alpha(+) intraepithelial lymphocyte differentiation
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SCOPUS
- Title
- Niche-specific MHC II and PD-L1 regulate CD4(+)CD8 alpha alpha(+) intraepithelial lymphocyte differentiation
- Authors
- Moon, Sookjin; Park, Yunji; Hyeon, Sumin; Kim, Young-Min; Kim, Ji-Hae; Kim, Hyekang; Park, Subin; Lee, Kun-Joo; Koo, Bon-Kyoung; Ha, Sang-Jun; Lee, Seung-Woo
- Date Issued
- 2021-04
- Publisher
- ROCKEFELLER UNIV PRESS
- Abstract
- Conventional CD4(+) T cells are differentiated into CD4(+)CD8 alpha alpha(+) intraepithelial lymphocytes (IELs) in the intestine; however, the roles of intestinal epithelial cells (IECs) are poorly understood. Here, we showed that IECs expressed MHC class II (MHC II) and programmed death-ligand 1 (PD-L1) induced by the microbiota and IFN-gamma in the distal part of the small intestine, where CD4(+) cells were transformed into CD4(+)CD8 alpha alpha(+) IELs. Therefore, IEC-specific deletion of MHC II and PD-L1 hindered the development of CD4(+)CD8 alpha alpha(+) IELs. Intracellularly, PD-1 signals supported the acquisition of CD8 alpha alpha by down-regulating the CD4-lineage transcription factor, T helper-inducing POZ/Kruppel-like factor (ThPOK), via the Src homology domain-containing tyrosine phosphatase (SHP) pathway. Our results demonstrate that noncanonical antigen presentation with cosignals from IECs constitutes niche adaptation signals to develop tissue-resident CD4(+)CD8 alpha alpha(+) IELs.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/106684
- DOI
- 10.1084/jem.20201665
- ISSN
- 0022-1007
- Article Type
- Article
- Citation
- JOURNAL OF EXPERIMENTAL MEDICINE, vol. 218, no. 4, 2021-04
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- There are no files associated with this item.
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