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Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors SCIE SCOPUS

Title
Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors
Authors
Seo, HanjinLee, Hyomin
Date Issued
2021-03
Publisher
AMER INST PHYSICS
Abstract
Recent advances in droplet microfluidics have led to the fabrication of versatile vesicles with a structure that mimics the cellular membrane. These artificial cell-like vesicles including polymersomes and liposomes effectively enclose an aqueous core with well-defined size and composition from the surrounding environment to implement various biological reactions, serving as a diverse functional reactor. The advantage of realizing various biological phenomena within a compartment separated by a membrane that resembles a natural cell membrane is actively explored in the fields of synthetic biology as well as biomedical applications including drug delivery, biosensors, and bioreactors, to name a few. In this Perspective, we first summarize various methods utilized in producing these polymersomes and liposomes. Moreover, we will highlight some of the recent advances in the design of these artificial cell-like vesicles for functional bioreactors and discuss the current issues and future perspectives.
URI
https://oasis.postech.ac.kr/handle/2014.oak/105138
DOI
10.1063/5.0048441
ISSN
1932-1058
Article Type
Article
Citation
BIOMICROFLUIDICS, vol. 15, no. 2, 2021-03
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이효민Lee, Hyomin
Dept. of Chemical Enginrg
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